Article
Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-α Pathway.
Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2022
Lin Chin-Hsien, Lin Han-Yi, Ho En-Pong, Ke Yi-Ci, Cheng Mei-Fang, Shiue Chyng-Yann, Wu Chi-Han, Liao Peng-Hsiang, Hsu Angela Yu-Huey, Chu Li-An, Liu Ya-Ding, Lin Ya-Hui, Tai Yi-Cheng, Shun Chia-Tung, Chiu Han-Mo, Wu Ming-Shiang
Abstract excerpt
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) is a common risk gene for Parkinson's disease (PD) and inflammatory bowel disorders. However, the penetrance of the most prevalent LRRK2 mutation, G2019S, is <50%. Factors other than genetic mutations are needed in PD process. OBJECTIVES: To examine whether and how gut inflammation may act as an environmental trigger to neurodegeneration in PD. METHODS: A mild and...
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