Article

LRRK2 G2019S promotes the development of colon cancer via modulating intestinal inflammation

2023-06-30

Abstract excerpt

LRRK2 G2019S is the most prevalent variant associated with Parkinson’s disease (PD), found in 1-3% of sporadic and 4-8% of familial PD cases. Intriguingly, emerging clinical studies have suggested that LRRK2 G2019S carriers have an increased risk of cancers including colorectal cancer. However, the underlying mechanisms of the positive correlation between LRRK2-G2019S and colorectal cancer remain unknown. Using a...

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Literature Corpus work: 4b67173a-29ae-5574-82a0-c439588d61c5
DOI: 10.1101/2023.06.28.546897

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