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Article

Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis.

Acta neuropathologica - 1 Aug 2023

Cabezudo Diego, Tsafaras George, Van Acker Eva, Van den Haute Chris, Baekelandt Veerle

Abstract excerpt

The link between the gut and the brain in Parkinson's disease (PD) pathogenesis is currently a subject of intense research. Indeed, gastrointestinal dysfunction is known as an early symptom in PD and inflammatory bowel disease (IBD) has recently been recognised as a risk factor for PD. The leucine-rich repeat kinase 2 (LRRK2) is a PD- and IBD-related protein with highest expression in immune cells. In this study,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37289222
DOI: 10.1007/s00401-023-02595-9
PMCID: PMC10328902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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