Mutations in tumor signaling, metastases, and synthetic lethality establish distinct patterns.

Abstract excerpt

Effective identification of oncogenic mutations is essential for diagnosis, forecasting resistance, and metastasis in remission. It is required for an optimal drug regimen. We develop a framework to discover mutations that co-exist in different oncoproteins, and those that are excluded, likely encoding oncogene-induced senescence. First, mapping the proteins onto pathways assists combinatorial drug selections and...

Topics

• Humans
• Neoplasm Metastasis
• Signal Transduction
• Mutation
• Synthetic Lethal Mutations
• Neoplasms
• Computational Biology