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Article

Non-coding germline <i>GATA3</i> variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

2020-02-25

Abstract excerpt

Inherited non-coding genetic variants confer significant disease susceptibility in many cancers. However, the molecular processes of by which germline variants contribute to somatic lesions are poorly understood. We performed targeted sequencing in 5,008 patients and identified a key regulatory germline variant in GATA3 strongly associated with Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like AL...

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Literature Corpus work
bb92da8e-cff9-5f91-8606-77728c650a37
DOI
10.1101/2020.02.23.961672
Open publication

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Non-coding germline <i>GATA3</i> variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemiaDOI 10.1101/2020.02.23.961672
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