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An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs

2025-06-24

Abstract excerpt

<title>Abstract</title> <p>EGFR amplification frequently happens within extrachromosome DNAs (ecDNAs) and is a major mutation in glioblastoma (GBM). However, targeting EGFR for GBM treatments has been unsuccessful. Here we characterized a long non-coding RNA (lncRNA) that is co-amplified with EGFR within ecDNAs that we name hidden EGFR long non-coding downstream RNA (HELDR). HELDR is a GBM-specific lncRNA that pr...

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Literature Corpus work
bb8dc01c-3063-5b30-82d9-f92104fcb5d0
DOI
10.21203/rs.3.rs-6456987/v1
Open publication

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An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene ProgramsDOI 10.21203/rs.3.rs-6456987/v1
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