Article

Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer

2025-01-27

Abstract excerpt

<h4>Summary</h4> In mammalian cells, gene copy number is tightly controlled to maintain gene expression and genome stability. However, a common molecular feature across cancer types is oncogene amplification, which promotes cancer progression by drastically increasing the copy number and expression of tumor-promoting genes. For example, in tyrosine kinase inhibitor (TKI)-resistant lung adenocarcinoma (LUAD), onco...

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Literature Corpus work: d14a7a5f-8eb8-5861-86ac-aa52730b97ff
DOI: 10.1101/2025.01.26.634826

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