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Article

Epigenetic Alterations in the Brain Associated with HIV-1 Infection and Methamphetamine Dependence

23 Jul 2014

Abstract excerpt

HIV involvement of the CNS continues to be a significant problem despite successful use of combination antiretroviral therapy (cART). Drugs of abuse can act in concert with HIV proteins to damage glia and neurons, worsening the neurotoxicity caused by HIV alone. Methamphetamine (METH) is a highly addictive psychostimulant drug, abuse of which has reached epidemic proportions and is associated with high-risk...

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PMID: 25054922
DOI: 10.1371/journal.pone.0102555

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