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Article

Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?

22 Mar 2011

Abstract excerpt

Human DDX3 is a DEAD (Asp-Glu-Ala-Asp)-box RNA helicase that appears to be a prime target for viral manipulation. While two viruses that manifest major global health threats, HIV and HCV (hepatitis C virus), utilize DDX3 for their replication, other viruses inhibit DDX3's newly identified function in innate antiviral signalling. This review discusses the role of DDX3 in antiviral immunity and its inhibition or...

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PMID: 21428961
DOI: 10.1042/bst0390679

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