Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

17 Dec 2015

Abstract excerpt

UNLABELLED: The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3). IRF3 plays a critical role in antiviral immunity to drive the expression of innate immune response...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Mosquito-borne diseases and control
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26676770
DOI: 10.1128/jvi.02202-15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR PathwayPMID 26676770Read ↗

Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2Semantic proximity Read ↗

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunitySemantic proximity Read ↗

Potential Broad-Spectrum Antiviral Agents: A Key Arsenal Against Newly Emerging and Reemerging Respiratory RNA VirusesSemantic proximity Read ↗

High content screening and computational prediction reveal viral genes that suppress innate immune responseSemantic proximity Read ↗

Discovery of Genes that Modulate Flavivirus Replication in an Interferon-Dependent MannerSemantic proximity Read ↗

Discovery of genes that modulate flavivirus replication in an interferon-dependent mannerSemantic proximity Read ↗

Antiviral strategies targeting herpesvirusesSemantic proximity Read ↗

How Flaviviruses Activate and Suppress the Interferon ResponseSemantic proximity Read ↗

IRF-1, RIG-I and MDA5 display potent antiviral activities against norovirus coordinately induced by different types of interferonsSemantic proximity Read ↗

Antiviral Signaling Through Pattern Recognition ReceptorsSemantic proximity Read ↗

The future of antiviralsSemantic proximity Read ↗

Small molecules targeting viral <scp>RNA</scp>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.