Article

Nucleobase clustering contributes to the formation and hollowing of repeat-expansion RNA condensate

2021-11-08

Abstract excerpt

RNA molecules with repeat expansion sequences can phase separate into gel-like condensate, and this process may lead to neurodegenerative diseases. Here we report that in the presence of Mg 2+ ion, RNA molecules containing 20×CAG repeats coacervate into filled droplets or hollowed condensate. Using hyperspectral stimulated Raman spectroscopy, we show that RNA coacervation is accompanied by the stacking and cluste...

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Literature Corpus work: bb835d37-aa66-5d30-93eb-c30f87bf4cdc
DOI: 10.1101/2021.11.08.467691

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