Article

Dual modulation of phase-transitioning licenses the Bicc1 network of ciliopathy proteins to bind specific target mRNAs

2021-10-10

Abstract excerpt

<h4>SUMMARY</h4> Perturbations in biomolecular condensates that form by phase-transitioning are linked to a growing number of degenerative diseases. For example, mutations in a multivalent interaction network of the Ankyrin (ANK) and sterile alpha motif (SAM) domain-containing ANKS3 and ANKS6 proteins with the RNA-binding protein Bicaudal-C1 (Bicc1) associate with laterality defects and chronic kidney diseases kn...

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Literature Corpus work: 01a04059-8a09-5def-a62e-5cdaecc64769
DOI: 10.1101/2021.10.07.463531

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