Article

Systematic generation and imaging of tandem repeats reveal multivalent base-pairing as a major determinant of RNA aggregation

2022-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Expansion of short tandem repeats (STRs) in the human genome underlies over fifty genetic disorders. A common pathological feature of repeat RNAs is their propensity to aggregate in cells. While these RNA aggregates have been shown to cause toxicity by sequestering RNA-binding proteins, the molecular mechanism of repeat RNA aggregation remains unclear. Here we devised a generalizable method to e...

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Literature Corpus work: 35325c89-fa38-5149-b44b-04763badc3c1
DOI: 10.1101/2022.04.11.487960

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