Article

Targeted RNA Condensation in Living Cells via Genetically Encodable Triplet Repeat Tags

2023-04-07

Abstract excerpt

Living systems contain various functional membraneless organelles that can segregate selective proteins and RNAs via liquid–liquid phase separation. Inspired by nature, many synthetic compartments have been engineered in vitro and in living cells, mostly focused on protein-scaffolded systems. Herein, we introduce a nature-inspired genetically encoded RNA tag to program cellular condensate formations and recruit no...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71a3ad46-e8af-56a1-9240-04d04d9dbb1b
DOI: 10.1101/2023.04.07.536084

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeted RNA Condensation in Living Cells via Genetically Encodable Triplet Repeat TagsDOI 10.1101/2023.04.07.536084Read

OptoChaperone – A biohybrid tool for regulating protein condensates in cells and <i>in vitro</i>Semantic proximity Read

Synthetic ribonucleoprotein granules regulate translation of a target mRNA in living cellsSemantic proximity Read

RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase SeparationSemantic proximity Read

Advances in Nucleotide Repeat Expansion Diseases: Transcription Gets in Phase.Semantic proximity Read

Nucleobase clustering contributes to the formation and hollowing of repeat-expansion RNA condensateSemantic proximity Read

Aberrant phase separation and cancer.Semantic proximity Read

Phase-separating enzyme-responsive condensates for inhalable delivery of biomacromoleculesSemantic proximity Read

DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS CondensatesSemantic proximity Read

DNA affects the phenotype of fuel-dependent coacervate droplets.Semantic proximity Read

Reaction-diffusion condensation generates a regulatable landscape for self-organizing subcellular structuresSemantic proximity Read

Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferaseSemantic proximity Read

Fluorinated RNA origami enables serum-stable nanodevices for sensing and targetingSemantic proximity Read