Article

The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

2023-01-31

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated ALS/FTD. The most common genetic cause of ALS/FTD is the expansion of the intronic hexanucleotide repeat (GGGGCC) n in C9orf72 . Here, we investigated the formation of nucleic-acid secondary structures in these expansion repeats, and their role in generati...

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Literature Corpus work: 5923c183-1b36-5000-85f6-f3d048dcca57
DOI: 10.1101/2023.01.31.526399

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