Article

RNA Gelation in Repeat Expansion Disorders

2017-01-23

Abstract excerpt

Expansions of short nucleotide repeats in the protein coding and non-coding regions of >30 genes produce a variety of neurological and neuromuscular disorders including Huntington’s disease (CAG repeats), muscular dystrophy (CTG repeats) and amyotrophic lateral sclerosis (GGGGCC repeats) [1-3]. Expression of expanded repeats alone is sufficient to recapitulate disease pathology in animal models [4-6]. Repeat-conta...

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Literature Corpus work: 3a23bd29-5e9a-5ce4-9f8f-2a85346e569b
DOI: 10.1101/100719

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