Article

RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase Separation

2025-11-01

Abstract excerpt

<h4>ABSTRACT</h4> FUS undergoes liquid-liquid phase separation (LLPS) to support essential cellular functions, but aberrant phase transitions promote toxic aggregation in neurodegenerative disease. Short RNA oligonucleotides can reverse this behavior, yet the structural determinants that govern RNA activity remain poorly defined. Here, we identify RNA G-quadruplexes (rG4s) as tunable structural motifs that potent...

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Literature Corpus work: 475c4262-6387-56fc-8501-8de99025e153
DOI: 10.1101/2025.10.31.685846

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