Article

Molecular origins of heterogeneous aging and spatial organization in RNA condensates

2026-08-27

Abstract excerpt

The molecular origins of aging of biomolecular condensates, which play a central role in cellular organization, is poorly understood. Here, we use coarse-grained molecular simulations to investigate how RNA sequence and chain connectivity govern condensate aging over extended timescales. Condensates formed by CAG-repeat RNA undergo pronounced aging characterized by progressive dynamical slowing, loss of ergodicity...

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Literature Corpus work: 1ea7a1d8-699a-5abf-acab-716b0a6b96e4
DOI: 10.64898/2026.08.27.747560

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