Article

NODAL/TGFβ signalling mediates the self-sustained stemness induced by <i>PIK3CA</i> <sup> <i>H1047R</i> </sup> homozygosity in pluripotent stem cells

2019-09-01

Abstract excerpt

Activating PIK3CA mutations are known “drivers” of human cancer and developmental overgrowth syndromes. We recently demonstrated that the “hotspot” PIK3CA H1047R variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In the present study, we combine high-depth transcriptomics, total proteomics and reverse-phase protein arrays to reveal potentially disease-rel...

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Literature Corpus work: bb808d91-efda-5213-bb3a-33e7ac016d78
DOI: 10.1101/753830

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