Article

Investigation of genetic PIK3CA activation in genome-edited human pluripotent stem cells

2019-01-01

Abstract excerpt

Mosaic, activating mutations in PIK3CA, the gene encoding the catalytic p110α subunit of class IA phosphatidylinositol 3-kinase (PI3K), are the cause of rare, developmental growth disorders collectively known as PIK3CA-Related Overgrowth Spectrum (PROS). Given the pressing need for targeted therapy and evidence for tissue- and cell lineage-specific distribution of PIK3CA mutations in PROS, developmental models of...

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Literature Corpus work: 5d4890e7-e7df-5e24-9c8f-bb537e5c1a93
DOI: 10.17863/cam.35662

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