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Longitudinal single cell RNA-sequencing of <i>Pik3ca</i> <sup>H1047R</sup> -driven mammary tumorigenesis reveals coordinated transformation of epithelial and fibroblast transcriptional states

2026-08-04

Abstract excerpt

Breast cancer is a heterogeneous disease in which a single oncogenic driver can give rise to divergent tumor phenotypes. How oncogenic mutations generate epithelial state plasticity and coordinately remodel the surrounding tissue remains incompletely understood. Here, we applied longitudinal single cell RNA-sequencing to trace the mammary landscape during Pik3ca H1047R -driven tumor progression in the mouse. We i...

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Literature Corpus work
b7877079-7bda-563b-8d77-c8430e4866f5
DOI
10.64898/2026.08.01.742267
Open publication

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Longitudinal single cell RNA-sequencing of <i>Pik3ca</i> <sup>H1047R</sup> -driven mammary tumorigenesis reveals coordinated transformation of epithelial and fibroblast transcriptional statesDOI 10.64898/2026.08.01.742267
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