Cancer-Associated STAT3 Mutations Maintain ES Cell Self-Renewal Through Phosphorylation-Independent Mechanisms.

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is essential for embryonic stem (ES) cell self-renewal, and its mutations are found in various human diseases. In this study, we investigated the effects of disease-associated STAT3 mutations (Y640F and G656insF) on ES cell properties. These mutations maintained ES cell self-renewal in the absence of LIF and MEK/GSK3 inhibitors. Although these mutants...

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• Cell Self Renewal
• Embryonic Stem Cells
• Leukemia Inhibitory Factor
• Mice
• Mutation