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Article

Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.

PLoS genetics - 1 Nov 2021

Madsen Ralitsa R, Erickson Emily C, Rueda Oscar M, Robin Xavier, Caldas Carlos, Toker Alex, Semple Robert K, Vanhaesebroeck Bart

Abstract excerpt

A PI3Kα-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene encoding p110α. Preclinical studies have suggested that the PI3K/AKT/mTOR signaling pathway influences stemness, a dedifferentiation-related cellular phenotype associated with aggressive cancer. However, to date, no direct evidence for such a correlation has been demonstrated in human tumors. In...

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Identifiers

PMID: 34762647
DOI: 10.1371/journal.pgen.1009876
PMCID: PMC8584750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.PMID 34762647Read ↗

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