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Article

Chromatin accessibility during human first-trimester neurodevelopment.

Nature - 1 Nov 2025

Mannens Camiel C A, Hu Lijuan, Lönnerberg Peter, Schipper Marijn, Reagor Caleb C, Li Xiaofei, He Xiaoling, Barker Roger A, Sundström Erik, Posthuma Danielle, Linnarsson Sten

Abstract excerpt

The human brain develops through a tightly organized cascade of patterning events, induced by transcription factor expression and changes in chromatin accessibility. Although gene expression across the developing brain has been described at single-cell resolution1, similar atlases of chromatin accessibility have been primarily focused on the forebrain2-4. Here we describe chromatin accessibility and paired gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38693260
DOI: 10.1038/s41586-024-07234-1
PMCID: PMC12589128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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