Article

Loss of p27 <sup>Kip1</sup> causes metabolic reprogramming and is sufficient to induce a Warburg effect and glutamine addiction in untransformed cells

2026-02-09

Abstract excerpt

The metabolic needs of a cell are tightly linked to its proliferative state and increasing evidence indicate an extensive bidirectional crosstalk between metabolic pathways and cell cycle regulators. In cancer cells, metabolism is reprogrammed to couple energetic needs and relentless proliferation. The cyclin/CDK inhibitor p27 Kip1 (p27) is frequently inactivated in cancers. p27 is also involved in multiple cellu...

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Literature Corpus work: bb525a5b-bee9-5d39-be64-c00a359020e1
DOI: 10.64898/2026.02.06.703945

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Loss of p27 <sup>Kip1</sup> causes metabolic reprogramming and is sufficient to induce a Warburg effect and glutamine addiction in untransformed cellsDOI 10.64898/2026.02.06.703945Read

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