Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease

3 Mar 2011

Abstract excerpt

A fundamental imperative for mammalian cells is to coordinate cell metabolism and growth with environmentally induced stress. This review focuses on three highly integrated networks-the phosphoinositide 3-kinase (PI3K) signaling cascade, intermediate metabolism, and autophagy-that work together to maintain cellular homeostasis under basal conditions and to drive cell-mass accumulation and cell cycle progression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Histone Deacetylase Inhibitors Research
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23294306
DOI: 10.1146/annurev-pharmtox-010611-134717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and DiseasePMID 23294306Read ↗

Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T‐cell‐mediated immunitySemantic proximity Read ↗

Intermediary metabolism: An intricate network at the crossroads of cell fate and functionSemantic proximity Read ↗

TOR, the Gateway to Cellular Metabolism, Cell Growth, and DiseaseSemantic proximity Read ↗

Autophagy—a key player in cellular and body metabolismSemantic proximity Read ↗

Integrating autophagy and metabolism in cancerSemantic proximity Read ↗

mTOR complex 2 is an integrator of cancer metabolism and epigenetics.Semantic proximity Read ↗

Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalanceSemantic proximity Read ↗

The Interplay between Dysregulated Metabolism and Epigenetics in CancerSemantic proximity Read ↗

The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization.Semantic proximity Read ↗

LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases.Semantic proximity Read ↗

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets.Semantic proximity Read ↗

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by nightSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.