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Article

mTOR complex 2 is an integrator of cancer metabolism and epigenetics.

Cancer letters - 28 May 2020

Masui Kenta, Harachi Mio, Cavenee Webster K, Mischel Paul S, Shibata Noriyuki

Abstract excerpt

Metabolic reprogramming is a central hallmark of cancer and is driven by abnormalites of oncogenes and tumor suppressors. This enables tumor cells to obtain the macromolecular precursors and energy needed for rapid tumor growth. Accelerated metabolism also translates into cancer cell aggression through epigenetic changes. The aberrant signaling cascades activated by oncogenes coordinate metabolic reprogramming...

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Identifiers

PMID: 32145344
DOI: 10.1016/j.canlet.2020.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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