Article
TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies.
Cancer letters - 28 May 2020
Wilkie Mark D, Anaam Emad A, Lau Andrew S, Rubbi Carlos P, Jones Terence M, Boyd Mark T, Vlatković Nikolina
Abstract excerpt
Patients with mutated TP53 have been identified as having comparatively poor outcomes compared to those retaining wild-type p53 in many cancers, including squamous cell carcinomas of the head and neck (SCCHN). We have examined the role of p53 in regulation of metabolism in SCCHN cells and find that loss of p53 function determines the Warburg effect in these cells. Moreover, this metabolic adaptation to loss of...
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