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Regulation of Metabolic Activity by p53

20 May 2017

Abstract excerpt

Metabolic reprogramming in cancer cells is controlled by the activation of multiple oncogenic signalling pathways in order to promote macromolecule biosynthesis during rapid proliferation. Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically compromised conditions provided by the tumour microenvironment. The tumour suppressor p53 interacts with the metabolic network at...

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PMID: 28531108
DOI: 10.3390/metabo7020021

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