Article
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Science (New York, N.Y.) - 22 May 2009
Vander Heiden Matthew G, Cantley Lewis C, Thompson Craig B
Abstract excerpt
In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect." Aerobic glycolysis is an inefficient way to generate adenosine 5'-triphosphate (ATP), however, and the advantage it confers to cancer cells has been unclear....
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