Article
Maintaining replication origins in the face of genomic change.
Genome research - 1 Oct 2012
Di Rienzi Sara C, Lindstrom Kimberly C, Mann Tobias, Noble William S, Raghuraman M K, Brewer Bonita J
Abstract excerpt
Origins of replication present a paradox to evolutionary biologists. As a collection, they are absolutely essential genomic features, but individually are highly redundant and nonessential. It is therefore difficult to predict to what extent and in what regard origins are conserved over evolutionary time. Here, through a comparative genomic analysis of replication origins and chromosomal replication patterns in...
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