Article

The Endosomal pH Regulator NHE9 is a Driver of Stemness in Glioblastoma

2021-10-07

Abstract excerpt

<h4>ABSTRACT</h4> A small population of self-renewing stem cells initiate tumors and maintain therapeutic resistance in glioblastoma. Given the limited treatment options and dismal prognosis for this disease there is urgent need to identify drivers of stem cells that could be druggable targets. Previous work showed that the endosomal pH regulator NHE9 is upregulated in glioblastoma and correlates with worse survi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb206162-a784-53e2-804c-d0d9cb3982c7
DOI: 10.1101/2021.10.07.463493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Endosomal pH Regulator NHE9 is a Driver of Stemness in GlioblastomaDOI 10.1101/2021.10.07.463493Read

Endosomal pH is an evolutionarily conserved driver of phenotypic plasticity in colorectal cancer.Semantic proximity Read

New trends in glioma cancer therapy: Targeting Na+/H+ exchangersSemantic proximity Read

Sodium hydrogen exchanger 9 NHE9 (SLC9A9) and its emerging roles in neuropsychiatric comorbidity.Semantic proximity Read

Acidic stress promotes a glioma stem cell phenotype.Semantic proximity Read

A Step Beyond pH: Electrochemical Network Deregulation in Cancer, Mechanisms, Consequences, and Therapeutic Implications: A Narrative ReviewSemantic proximity Read

Cell Settling, Migration, and Stochastic Cancer Expression Suggest Potassium Flux Per H <sup>+</sup> - Sensitive KCN Members Associated with Oncogenes and Histone/DNA Modulators Potentially Initiates pH-ReversalSemantic proximity Read

Acidic pH of early endosomes governs SARS-CoV-2 transport in host cellsSemantic proximity Read

V-ATPase Proton Pump May Take Part to Drug-Resistance Phenotype of Glioma Stem CellsSemantic proximity Read

Vacuolar Proton-Translocating ATPase May Take Part in the Drug Resistance Phenotype of Glioma Stem Cells.Semantic proximity Read

The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking.Semantic proximity Read

Direct endosomal acidification by the outwardly rectifying CLC-5 Cl(-)/H(+) exchanger.Semantic proximity Read

Acidic pH with coordinated reduction of basic fibroblast growth factor maintains the glioblastoma stem cell-like phenotype in vitro.Semantic proximity Read