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Article

Acidic stress promotes a glioma stem cell phenotype.

Cell death and differentiation - 1 May 2011

Hjelmeland A B, Wu Q, Heddleston J M, Choudhary G S, MacSwords J, Lathia J D, McLendon R, Lindner D, Sloan A, Rich J N

Abstract excerpt

Malignant gliomas are lethal cancers that display cellular hierarchies with cancer stem cells at the apex. Glioma stem cells (GSCs) are not uniformly distributed, but rather located in specialized niches, suggesting that the cancer stem cell phenotype is regulated by the tumor microenvironment. Indeed, recent studies show that hypoxia and its molecular responses regulate cancer stem cell maintenance. We now...

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Source

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Identifiers

PMID: 21127501
DOI: 10.1038/cdd.2010.150
PMCID: PMC3095828

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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