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Article

Vacuolar Proton-Translocating ATPase May Take Part in the Drug Resistance Phenotype of Glioma Stem Cells.

International journal of molecular sciences - 27 Feb 2024

Giambra Martina, Di Cristofori Andrea, Raimondo Francesca, Rigolio Roberta, Conconi Donatella, Chiarello Gaia, Tabano Silvia Maria, Antolini Laura, Nicolini Gabriella, Bua Miriam, Ferlito Davide, Carrabba Giorgio, Giussani Carlo Giorgio, Lavitrano Marialuisa, Bentivegna Angela

Abstract excerpt

The vacuolar proton-translocating ATPase (V-ATPase) is a transmembrane multi-protein complex fundamental in maintaining a normal intracellular pH. In the tumoral contest, its role is crucial since the metabolism underlying carcinogenesis is mainly based on anaerobic glycolytic reactions. Moreover, neoplastic cells use the V-ATPase to extrude chemotherapy drugs into the extra-cellular compartment as a drug...

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Identifiers

PMID: 38473989
DOI: 10.3390/ijms25052743
PMCID: PMC10932054

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