Article

V-ATPase Proton Pump May Take Part to Drug-Resistance Phenotype of Glioma Stem Cells

2024-02-01

Abstract excerpt

The vacuolar proton translocating ATPase (V-ATPase) is a transmembrane multi-protein complex fundamental in maintaining a normal intracellular pH. In the tumoral contest, its role is crucial since the metabolism is mainly based on anaerobic glycolytic reactions. Moreover, the neoplastic cells use the V-ATPase to extrude chemotherapy drugs to the extra-cellular compartment, as a drug-resistance mechanism. In gliobl...

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Literature Corpus work: fac04294-449e-5a50-a009-7fb11f6a5be3
DOI: 10.20944/preprints202402.0078.v1

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