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Article

Direct endosomal acidification by the outwardly rectifying CLC-5 Cl(-)/H(+) exchanger.

The Journal of physiology - 15 Jun 2010

Smith Andrew J, Lippiat Jonathan D

Abstract excerpt

The voltage-gated Cl(-) channel (CLC) family comprises cell surface Cl(-) channels and intracellular Cl(-)/H(+) exchangers. CLCs in organelle membranes are thought to assist acidification by providing a passive chloride conductance that electrically counterbalances H(+) accumulation. Following recent descriptions of Cl(-)/H(+) exchange activity in endosomal CLCs we have re-evaluated their role. We expressed human...

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Identifiers

PMID: 20421284
DOI: 10.1113/jphysiol.2010.188540
PMCID: PMC2911210

Genes

CLC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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