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Article

TransHLA: a Hybrid Transformer model for HLA-presented epitope detection.

GigaScience - 6 Jan 2025

Lu Tianchi, Wang Xueying, Nie Wan, Huo Miaozhe, Li Shuaicheng

Abstract excerpt

BACKGROUND: Precise prediction of epitope presentation on human leukocyte antigen (HLA) molecules is crucial for advancing vaccine development and immunotherapy. Conventional HLA-peptide binding affinity prediction tools often focus on specific alleles and lack a universal approach for comprehensive HLA site analysis. This limitation hinders efficient filtering of invalid peptide segments. RESULTS: We introduce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40036690
DOI: 10.1093/gigascience/giaf008
PMCID: PMC11878767

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