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Dnmt3a -mutated clonal hematopoiesis promotes osteoporosis

25 Sept 2021

Abstract excerpt

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hematopoiesis of indeterminate potential (CHIP). Analyzing exome sequencing data from the UK Biobank, we found CHIP to be associated with increased incident osteoporosis...

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PMID: 34698806
DOI: 10.1084/jem.20211872

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