Article

Metformin reduces the clonal fitness of Dnmt3aR878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state

2024-02-06

Abstract excerpt

<title>Abstract</title> <p>Clonal hematopoiesis (CH) arises when a hematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type (WT) HSCs, resulting in its clonal expansion. Individuals with CH are at an increased risk of developing hematologic neoplasms and a range of age-related inflammatory illnesses1-3. Therapeutic interventions that suppress the expansion of mutant HS...

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Literature Corpus work: 8a14cf27-3082-5b11-95d2-626346da9906
DOI: 10.21203/rs.3.rs-3874821/v1

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