Article

D-glucuronyl C5-epimerase binds to EGFR to suppress kidney fibrosis

2024-11-28

Abstract excerpt

Renal tubular cells may actively participate in fibrosis processes leading to end-stage renal failure. However, which molecule play pivotal role in the fibrogenesis is still vague. Glucuronyl C5-epimerase ( Hsepi , gene name, Glce ) is a key enzyme that catalyzes biosynthesis of Heparan sulfate (HS) chains attached to HS proteoglycan which are ubiquitously located on cell membrane. Homozygous Glce -/- mice may...

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Literature Corpus work: bb08054e-1fd6-57e3-90ab-a113858ed29d
DOI: 10.1101/2024.11.25.625114

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