Article

Matrix Protein Tenascin-C Promotes Kidney Fibrosis via STAT3 activation in Response to Tubular Injury

2022-10-10

Abstract excerpt

Accumulating evidence indicates that the extracellular matrix (ECM) is not only a consequence of fibrosis, but also contributes to the progression of fibrosis, by creating a pro-fibrotic microenvironment. Tenascin-C (TNC) is an ECM glycoprotein that contains multiple functional domains. We showed that following kidney injury, TNC was markedly induced in fibrotic areas in the kidney from both mouse models and human...

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Literature Corpus work: e5ef43fd-61d5-575d-b6d7-707a1bc67103
DOI: 10.21203/rs.3.rs-2002214/v1

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