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Article

Heparanase is essential for the development of diabetic nephropathy in mice.

Diabetes - 1 Jan 2012

Gil Natali, Goldberg Rachel, Neuman Tzahi, Garsen Marjolein, Zcharia Eyal, Rubinstein Ariel M, van Kuppevelt Toin, Meirovitz Amichay, Pisano Claudio, Li Jin-Ping, van der Vlag Johan, Vlodavsky Israel, Elkin Michael

Abstract excerpt

Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Loss of GBM HS in diabetic kidney was associated with increased glomerular expression of heparanase; however, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

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Source

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Identifiers

PMID: 22106160
DOI: 10.2337/db11-1024
PMCID: PMC3237641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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