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Article

Characterization and expression of highly active recombinant human glucuronyl C5-epimerase in mammalian cells.

Glycobiology - 3 Jun 2023

Cui Hao, Li Qingwen, Wang Peipei, Fang Jianping

Abstract excerpt

Heparin, a highly sulfated and epimerized form of heparan sulfate, is a linear polysaccharide with anticoagulant activity widely used in the clinic to prevent and treat thrombotic diseases. However, there are several noteworthy drawbacks associated with animal-sourced heparin during the preparation process. The in vitro enzymatic synthesis of heparin has become a promising substitute for animal-derived heparin....

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PMID: 36912112
DOI: 10.1093/glycob/cwad021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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