Protective role of renal D-Glucuronyl C5-Epimerase (Glce) in the pathogenesis of kidney fibrosis

Abstract excerpt

<title>Abstract</title> <p>Fibrosis is a common pathway leading to end-stage renal failure and poses a huge threat to human health. However, the molecular mechanisms driving the fibrotic process remain poorly defined. Glucuronyl C5-epimerase (<italic>Hsepi</italic>, gene name, <italic>Glce</italic>) is a key enzyme in the biosynthesis of the heparin sulfate chains and previous studies have demonstrated homozygous...

Topics

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• Bone and Bones
• Carbohydrate Epimerases
• Gene Targeting
• Heparitin Sulfate
• Kidney
• Lung
• Mice, Knockout
• Structure-Activity Relationship

Identifiers and source

Literature Corpus work

8a9a2df1-7386-59c7-a48f-f87c1b4a83bd

DOI

10.21203/rs.3.rs-2189421/v1