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Article

Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.

American journal of physiology. Renal physiology - 1 Mar 2016

Takashima Yasutoshi, Keino-Masu Kazuko, Yashiro Hiroshi, Hara Satoshi, Suzuki Tomo, van Kuppevelt Toin H, Masu Masayuki, Nagata Michio

Abstract excerpt

Glomerular integrity and functions are maintained by growth factor signaling. Heparan sulfate, the major component of glomerular extracellular matrixes, modulates growth factor signaling, but its roles in glomerular homeostasis are unknown. We investigated the roles of heparan sulfate 6-O-endosulfatases, sulfatase (Sulf)1 and Sulf2, in glomerular homeostasis. Both Sulf1 and Sulf2 were expressed in the glomeruli...

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Identifiers

PMID: 26764203
DOI: 10.1152/ajprenal.00445.2015

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