Article

Ultrasensitive fitness costs arise from membrane proteome displacement under protein overexpression

2025-02-16

Abstract excerpt

Protein overexpression is crucial in many diseases and can lead to antibiotic resistance by increasing the expression of drug targets or resistance genes, such as membrane-localized efflux pumps. Using a high-throughput colony-imaging technique, we performed a quantitative genome-wide study of protein overexpression in Escherichia coli . Our results show that most membrane proteins impose steep overexpression cos...

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Literature Corpus work: bb06e7a9-44fa-50ff-893f-c53b842d9abf
DOI: 10.1101/2025.02.12.637850

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