Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic landscape of a bacterial cell.

Cell - 7 Jan 2011

Nichols Robert J, Sen Saunak, Choo Yoe Jin, Beltrao Pedro, Zietek Matylda, Chaba Rachna, Lee Sueyoung, Kazmierczak Krystyna M, Lee Karis J, Wong Angela, Shales Michael, Lovett Susan, Winkler Malcolm E, Krogan Nevan J, Typas Athanasios, Gross Carol A

Abstract excerpt

The explosion of sequence information in bacteria makes developing high-throughput, cost-effective approaches to matching genes with phenotypes imperative. Using E. coli as proof of principle, we show that combining large-scale chemical genomics with quantitative fitness measurements provides a high-quality data set rich in discovery. Probing growth profiles of a mutant library in hundreds of conditions in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genome, Bacterial

Share to Genomics

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 21185072
DOI: 10.1016/j.cell.2010.11.052
PMCID: PMC3060659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic landscape of a bacterial cell.PMID 21185072Read ↗

A fine scale phenotype-genotype virulence map of a bacterial pathogen.Semantic proximity Read ↗

Parallel Mapping of Antibiotic Resistance Alleles in Escherichia coli.Semantic proximity Read ↗

A genome-wide atlas of antibiotic susceptibility targets and pathways to toleranceSemantic proximity Read ↗

Quantitative approaches to study phenotypic effects of large-scale genetic perturbations.Semantic proximity Read ↗

Evidence-based annotation of gene function in Shewanella oneidensis MR-1 using genome-wide fitness profiling across 121 conditions.Semantic proximity Read ↗

Towards an informative mutant phenotype for every bacterial gene.Semantic proximity Read ↗

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical geneticsSemantic proximity Read ↗

Comparative analysis of gene importance in Escherichia coli across growth conditions.Semantic proximity Read ↗

A genome-wide atlas of antibiotic susceptibility targets and pathways to toleranceSemantic proximity Read ↗

Growth dynamics of 3,909 Escherichia coli single-gene knockouts in rich and minimal media.Semantic proximity Read ↗

Genetic architecture of intrinsic antibiotic susceptibility.Semantic proximity Read ↗

The impact of genetic diversity on gene essentiality within the Escherichia coli species.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.