Article
ATP sequestration by a synthetic ATP-binding protein leads to novel phenotypic changes in Escherichia coli.
ACS chemical biology - 15 Feb 2013
Korch Shaleen B, Stomel Joshua M, León Megan A, Hamada Matt A, Stevenson Christine R, Simpson Brent W, Gujulla Sunil K, Chaput John C
Abstract excerpt
Artificial proteins that bind key metabolites with high affinity and specificity hold great promise as new tools in synthetic biology, but little has been done to create such molecules and examine their effects on living cells. Experiments of this kind have the potential to expand our understanding of cellular systems, as certain phenotypes may be physically realistic but not yet observed in nature. Here, we...
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