Females outperform males in spatial learning despite increased amyloid plaques and microgliosis in a TgF344-AD rat model of Alzheimer’s disease

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and is the sixth leading cause of death in the US. AD is more prevalent in females than males. While estrogen provides neuroprotection in females, sex mediated differences in the development of AD pathology are not fully elucidated. Therefore, a comparison of the events that develop between sexes in the early-stage of AD pathology may reveal new p...

Topics

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• Alzheimer Disease
• Amyloid beta-Protein Precursor
• Disease Models, Animal
• Mice, Inbred C57BL
• Mice, Transgenic
• Pathology, Molecular
• Presenilin-1
• Sex Characteristics

Identifiers and source

Literature Corpus work

1650a249-76f2-56a6-88a2-5673ad773fa8

DOI

10.1101/2022.03.27.485975