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Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

18 May 2015

Abstract excerpt

Alzheimer's disease (AD) is a complex, multifactorial disease with a number of leading mechanisms, including neuroinflammation, processing of amyloid precursor protein (APP) to amyloid β peptide, tau protein hyperphosphorylation, relocalization, and deposition. These mechanisms are propagated by obesity, the metabolic syndrome and type-2 diabetes mellitus. Stress, sedentariness, dietary overconsumption of...

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PMID: 26041981
DOI: 10.3389/fnins.2015.00173

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